Sleep-waking cycle

The states of sleep
Michel Jouvet
Light and deep sleep differ physiologically, deep sleep having much in common with being awake. Studies with cats now suggest that the two states of sleep are induced by different biochemical secretions.

Paradoxical sleep mechanisms
Michel Jouvet (1961)
Since there are excellent recent reviews concerned with paradoxical sleep (PS) or REM sleep mechanisms, it is unecessary to give an overwiew of these reviews. However the following topics need some discussion either because they have not yet received any unequivocal solution or because they were not examined in these reviews.

Neurophysiology of the States of Sleep
Michel Jouvet (1967)
As long as we do not know how and why sleep forces on us a necessary and recurrent change in the process of our relations with our environment, it is impossible to give a definition of sleep that would satisfy everybody. Indeed the causes and mechanisms of sleep remain unknown despite a great amount of work...

Paradoxical Sleep - A Study of its Nature and Mechanisms
Michel Jouvet (1965)
It has recently been discovered that during behavioural sleep there periodically occurs a state characterized by fast cortical activity similar to that of the waking state, accompanied by a complete disappearance of muscular tonus and of rapid eye movements (Dement, 1958; M. Jouvet et al., 1959). This gives rise to the following problem: Should we consider "classic" sleep, with its slow cortical waves (slow sleep), and paradoxical sleep (P.S.) to be the expression of a single hypnogenic mechanism? On the basis of this hypothesis, P.S. would represent no more than the overstatement of an active hypnic process, since in adults P.S. almost always follows slow sleep and is the deepest state of sleep.

Biogenic Amines and the States of Sleep
Michel Jouvet (1969)
In the past 10 years the study of sleep mechanisms has developed very rapidly and has become one of the major fields of neurophysiological and psychological research. This rapid growth is in part due to some discoveries which have changed the classical neurophysiological picture of sleep from the concept of a passive resting state of the brain to that of a heterogeneous and complicated suc cession of active phenomena...

Telencephalic and rhombencephalic sleep in the cat
Michel Jouvet (1961)
A brief review of the physiological data relating to the nature of sleep enables us to get an idea of the duality of structures and mechanisms brought into play during this periodic mystery...