Single Molecule Fluorescence Detection 

SMFD Home Page

The BBSRC has recently awarded a research grant to the VUV-IR group at CLRC Daresbury Laboratory to built a fluorescence microscope for single transmembrane receptor studies in living cells. The full text of the research application can be found here.
 

The microscope will be used to collect single pair fluorescence resonance energy transfer (smFRET) and  single molecule fluorescence polarisation (smFP) from a physiologically relevant group of receptors in a living cell. The SM data obtained from the new facility will provide information on, for example:


 
 
 
 
 
Extracellular Domain

Plasma Membrane

Intracellular Domain


 
 
 

 

Workshop on SMFD at Daresbury Laboratory on the 20/11/02
 


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Last update 3 October 2002