11 December, 2008
Volume 4, Issue 6

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Volume 4, Issue 6

On the cover: The malaria causing Plasmodium parasites must coordinate the salvage of host factors with de novo biosynthesis pathways in order to meet the unique demands of each intracellular stage of their life cycle. In this issue, Yu, Fidock, and colleagues (pp. 567–578) report that the parasite's fatty acid biosynthesis enzyme FabI is required for the liver stages of Plasmodium development but is dispensable for its growth in the blood stage. Cover shows the three phases of Plasmodium liver-stage development: schizont (magenta), cytomere (light green), and merozoite (yellow). Hepatoma cells infected with P. berghei sporozoites were stained with antisera against parasite SERA proteases and the exported protein 1, localizing in the parasitophorous vacuole membrane. Colors were computer generated to label the different parasite stages. Nuclei (blue) were stained with Hoechst.

Most Read Papers

Awards & Recognition

  • The Nobel Prize in Physiology or Medicine for 2008 was recently awarded to Harald zur Hausen for his work on HPV and to Françoise Barré-Sinoussi and Luc Montagnier jointly for their discovery of HIV. In a BenchMark article in the latest issue of Cell, Robin Weiss provides a historical viewpoint of these discoveries.
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Chlamydia-containing vacuole expanding as the bacteria replicate, filling the host cell cytoplasm. Time-lapse microscopy for 20 hr. Movie by Kumar and Valdivia. Also see the paper by Huang et al. in the current issue.

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Featured Job

Senior Scientists and Scientists

Genentech, Inc. is currently seeking Senior Scientists and Scientists in our Department of Microbial Pathogenesis in our South San Francisco headquarters. All positions require a PhD, MD or PhD/MD. For 30 years, Genentech has been at the forefront of the biotechnology industry, using human genetic information to develop novel medicines for serious and life-threatening diseases. Today, Genentech is among the world's leading biotech companies, with multiple therapies on the market. For more information, click here.

In the December Issue

Structures of a Chlamydia Protease
Extracellular Pathogen DNA induces Type I IFN Response
Host Lipoproteins Antagonize Staphylococcus Quorum Sensing
Fatty Acid Biosynthesis during Plasmodium Liver Stage Infection
Generation and Function of a Flavivirus Noncoding RNA
A Revised Model for HIV-1 Morphogenesis
A Prefusion Intermediate of Alphavirus Membrane Fusion

Meeting Review: EMBO conference "At the joint edge of Cellular Microbiology and Cell Biology"
Review: Molecular Chaperones in Pathogen Virulence

Click here for the complete table of contents.

Next issue: January 22, 2008

Featured Article

The Featured Article is freely available to all readers.

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

Gorben P. Pijlman, Anneke Funk, Natasha Kondratieva, Jason Leung, Shessy Torres, Lieke van der Aa, Wen Jun Liu, Ann C. Palmenberg, Pei-Yong Shi, Roy A. Hall, and Alexander A. Khromykh

Khromykh Pijlman et al. discover that flavivirus, a group of medically important encephalitic RNA viruses, exploit the action of host nucleases to produce a unique, highly structured noncoding RNA, which is essential for virus-induced cytopathicity and pathogenicity. Preview by Pierson.

Issue Highlights

Golenbock Charrel-Dennis et al. report that the extracellular bacterial pathogen, group B streptococcus (GBS) induces type I interferon production in infected macrophages via the intracellular recognition of GBS DNA.
Fidock Yu et al. show that Plasmodium fatty acid synthesis enzyme FabI is required for liver infection, yet is not the principle target in parasites of the FabI inhibitor triclosan. Preview by Spalding and Prigge.
Gresham Peterson et al. show that blood-borne apolipoprotein B sequesters the Staphylococcus aureus quorum sensing signal, thereby inhibiting invasive infection. Preview by Horswill and Nauseef.

Host-Microbe Papers in Other Cell Press Journals

Current Biology, December 2008

Plant Pattern-Recognition Receptor FLS2 Is Directed for Degradation by the Bacterial Ubiquitin Ligase AvrPtoB
Vera Göhre, Thomas Spallek, Heidrun Häweker, Sophia Mersmann, Tobias Mentzel, Thomas Boller, Marta de Torres, John W. Mansfield, and Silke Robatzek

Immunity, December 2008

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control
Stephen A. Migueles, Christine M. Osborne, Cassandra Royce, Alex A. Compton, Rohan P. Joshi, Kristin A. Weeks, Julia E. Rood, Amy M. Berkley, Jonah B. Sacha, Nancy A. Cogliano-Shutta et al.

Trends in Parasitology, December 2008 FREE

Recent insights into humoral and cellular immune responses against malaria
James G. Beeson, Faith H.A. Osier, and Christian R. Engwerda

Chemistry & Biology, November 2008

N-Acylhomoserine Lactone-Mediated Quorum Sensing: A Twist in the Tail and a Blow for Host Immunity
Margaret Cooley, Siri Ram Chhabra, and Paul Williams