4 December, 2008
Volume 3, Issue 6

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Volume 3, Issue 6

On the cover: While close associations exist between hematopoietic stem cells (HSCs) and the endothelium throughout development, there has been some question as to whether HSCs can originate from the endothelium, or simply migrate through the vasculature to gain access to the circulation. Using a temporal genetic tracing strategy, Zovein et al. (p. 625) demonstrate that HSCs do emerge from endothelial cells. The cover shows a murine umbilical artery with HSC clusters attached to the underlying endothelium. The endothelium and HSCs are shown in blue, signifying a common origin, as fate mapped by an endothelial Cre line. This image was processed using Adobe Photoshop CS.

In the News

Most Read Papers

  • These are the Top 20 papers by download from the Cell Stem Cell web site for the last 30 days.

The ISSCR releases new Translational Guidelines

In this issue, an ISSCR Commentary article outlines their proposed Guidelines for the Clinical Translation of Stem Cells, available in full online at the ISSCR website. The recommendations include an insistence on expert evaluation and independent oversight, a thorough informed consent process, and transparency in reporting of clinical trial results.

Complementing the release of the Guidelines, in a Correspondence article Caulfield and colleagues assess the online portrayal of stem cell commercial ventures and reveal that most clinics exaggerate claims and omit risks.

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In the December Issue

Research articles:
c-Myc and N-Myc in HSC function and survival
An endothelial origin for HSCs
hESC-derived cells as a tool for studying ALS (Di Giorgio et al., Marchetto et al.)
Neurofibroma from peripheral nerve progenitors
Imaging CNS stem cell lineages
In the Review section:
Protocol review on generation of iPSCs
Minireview on the site of HSC emergence
Correspondence on stem cell clinics
In the ISSCR section:
New Translational Research Guidelines

Click here for the complete table of contents.

Featured Article

Access to the featured articles is free for all readers

ALS Model Glia Can Mediate Toxicity to Motor Neurons Derived from Human Embryonic Stem Cells
The Gage and Eggan laboratories independently use human spinal motor neurons derived from human embryonic stem cells to screen for potential sources of the toxic effect induced by cocultured human glial cells that carry an ALS-causing SOD1 gene mutation. Both laboratories identify candidate soluble mediators of the astrocyte-dealt death, including superoxide and prostaglandin.

Editors' Notes Highlights

Pluripotency for Everyone
In their Protocol Review, Maherali and Hochedlinger summarize the current requirements for inducing pluripotency in somatic cells and compare the various approaches used by different laboratories. Also in this issue, Deng and colleagues describe the isolation of iPSCs from monkey cells, demonstrating that the same reprogramming factors that work for mouse and human cells are also sufficient to induce pluripotency in another species.

Stem Cell Articles in Other Cell Press Journals

Molecular Cell 32 (4) p. 491 November 21, 2008

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency
Xiaohua Shen, Yingchun Liu, Yu-Jung Hsu, Yuko Fujiwara, Jonghwan Kim, Xiaohong Mao, Guo-Cheng Yuan, and Stuart H. Orkin

Cell 135 (4) p. 649 November 14, 2008

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment
Menno P. Creyghton, Styliani Markoulaki, Stuart S. Levine, Jacob Hanna, Michael A. Lodato, Ky Sha, Richard A. Young, Rudolf Jaenisch, and Laurie A. Boyer

Developmental Cell 15 (5) p. 773 November 11, 2008

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis
Jungmook Lyu, Vicky Yamamoto, and Wange Lu

Cell 135 (3) p. 449 October 31, 2008

The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
Yu-Fen Chou, Hsu-Hsin Chen, Maureen Eijpe, Akiko Yabuuchi, Joshua G. Chenoweth, Paul Tesar, Jun Lu, Ronald D.G. McKay, and Niels Geijsen