4 December, 2008
Volume 3, Issue 6
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Volume 3, Issue 6
On the cover: While close associations exist between hematopoietic stem cells (HSCs) and the endothelium throughout development, there has been some question as to whether HSCs can originate from the endothelium, or simply migrate through the vasculature to gain access to the circulation. Using a temporal genetic tracing strategy, Zovein et al. (p. 625) demonstrate that HSCs do emerge from endothelial cells. The cover shows a murine umbilical artery with HSC clusters attached to the underlying endothelium. The endothelium and HSCs are shown in blue, signifying a common origin, as fate mapped by an endothelial Cre line. This image was processed using Adobe Photoshop CS.
In the News
- Read coverage of recent Cell Stem Cell articles in the popular press.
Most Read Papers
- These are the Top 20 papers by download from the Cell Stem Cell web site for the last 30 days.
The ISSCR releases new Translational Guidelines
- In this issue, an ISSCR Commentary article outlines their proposed Guidelines for the Clinical Translation of Stem Cells, available in full online at the ISSCR website. The recommendations include an insistence on expert evaluation and independent oversight, a thorough informed consent process, and transparency in reporting of clinical trial results.
Complementing the release of the Guidelines, in a Correspondence article Caulfield and colleagues assess the online portrayal of stem cell commercial ventures and reveal that most clinics exaggerate claims and omit risks.- In this issue, an ISSCR Commentary article outlines their proposed Guidelines for the Clinical Translation of Stem Cells, available in full online at the ISSCR website. The recommendations include an insistence on expert evaluation and independent oversight, a thorough informed consent process, and transparency in reporting of clinical trial results.
ISSCR Members
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- Cell Stem Cell is the official affiliated journal of the International Society for Stem Cell Research (ISSCR).
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Featured Job
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In the ISSCR section:
In the December Issue
Research articles:Click here for the complete table of contents.
Featured Article
Access to the featured articles is free for all readers
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The Gage and Eggan laboratories independently use human spinal motor neurons derived from human embryonic stem cells to screen for potential sources of the toxic effect induced by cocultured human glial cells that carry an ALS-causing SOD1 gene mutation. Both laboratories identify candidate soluble mediators of the astrocyte-dealt death, including superoxide and prostaglandin. |
Editors' Notes Highlights
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Pluripotency for Everyone In their Protocol Review, Maherali and Hochedlinger summarize the current requirements for inducing pluripotency in somatic cells and compare the various approaches used by different laboratories. Also in this issue, Deng and colleagues describe the isolation of iPSCs from monkey cells, demonstrating that the same reprogramming factors that work for mouse and human cells are also sufficient to induce pluripotency in another species. |
Stem Cell Articles in Other Cell Press Journals
Molecular Cell 32 (4) p. 491 November 21, 2008
Xiaohua Shen, Yingchun Liu, Yu-Jung Hsu, Yuko Fujiwara, Jonghwan Kim, Xiaohong Mao, Guo-Cheng Yuan, and Stuart H. OrkinCell 135 (4) p. 649 November 14, 2008
Menno P. Creyghton, Styliani Markoulaki, Stuart S. Levine, Jacob Hanna, Michael A. Lodato, Ky Sha, Richard A. Young, Rudolf Jaenisch, and Laurie A. BoyerDevelopmental Cell 15 (5) p. 773 November 11, 2008
Jungmook Lyu, Vicky Yamamoto, and Wange LuCell 135 (3) p. 449 October 31, 2008
Yu-Fen Chou, Hsu-Hsin Chen, Maureen Eijpe, Akiko Yabuuchi, Joshua G. Chenoweth, Paul Tesar, Jun Lu, Ronald D.G. McKay, and Niels Geijsen