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October 6 - October 10, 2008


Cell - An overload of calories throws critical portions of the brain out of whack, reveals a new study. That response in the brain’s hypothalamus—the “headquarters” for maintaining energy balance—can happen even in the absence of any weight gain, according to the new studies in mice.

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MSNBC.com | Los Angeles Times | BBC | US News and World Report | United Press International (UPI) | Marie Claire Magazine | The Independent (UK) | USA Today

Cell Metabolism - A fatty acid found in abundance in olive oil and other “healthy” unsaturated fats has yet another benefit: it helps keep the body satisfied to prolong the time between meals. A new study reveals that once this type of fat, known as oleic acid, reaches the intestine, it is converted into a lipid hormone (oleoylethanolamide, or OEA) that wards off the next round of hunger pangs. The researchers said it may be the first description of an ingredient in food that directly provides the raw materials for a hormone’s production.

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US News and World Report | Daily Mail (UK) | The Times of India | The Telegraph (UK)

Neuron - New research findings suggest that structural abnormalities in the brains of cocaine addicts are related in part to drug use and in part to a predisposition toward addiction. The research maps the topography of the addicted brain and provides new insight into the effect of cocaine on neural systems mediating cognition and motivation.

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Reuters | Thaindian.com

Cancer Cell – New research suggests that the identification and examination of key cell signaling events required for initiation and progression of cancer might be best accomplished at the single cell level. The research provides new insight that may lead to better diagnosis and treatment of some complex cancers.

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Forbes Magazine

Neuron – A new animal model has provided insight into the cellular and molecular mechanisms associated with behavioral therapy for depression. The study may provide a good model system for testing cellular and molecular interactions between antidepressive medications and behavioral treatments for depression.

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National Post (Canada) | The Telegraph (UK) | The Metro (UK) | Glasgow Daily Record (UK)

Neuron – A cell protein routinely used as a diagnostic for prostate cancer appears to also work as a pain medication that is far more effective than morphine but with far fewer side effects, a new report says.

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Washington Post

Cell Stem Cell - Notch signaling was altered within mammary epithelial subsets by either knockdown of the canonical Notch effector gene Cbf-1 or constitutive activation of the pathway. Notch signaling represses stem cell expansion and directs luminal cell fate determination. Interestingly, constitutive signaling was found to specifically target luminal progenitors for expansion and self-renewal.

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Canberra Times (Australia)

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Cell Press primary research journals include the flagship journal Cell, as well as Neuron, Immunity, Molecular Cell, Developmental Cell, Cancer Cell, Current Biology, Structure, Chemistry & Biology, Cell Metabolism, Cell Host & Microbe, Cell Stem Cell and, new to Cell Press in 2008, The American Journal of Human Genetics. Also new to Cell Press this year are the fourteen Trends reviews journals, including Trends in Cell Biology and Trends in Neuroscience.

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