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Volume 135, Issue 6
On the cover: Hematopoietic cancers, such as the follicular lymphoma pictured on the cover, frequently contain chromosomal translocations. However, the molecular mechanisms behind these DNA breakage and reshuffling events are largely unidentified. In this issue of Cell, Tsai et al. (pp. 1130–1142) show that CpG dinucleotides, like that colored in the molecular structure on the cover, are hotspots for pro-B/pre-B stage translocations—the most common translocations in human cancer. On the basis of the molecular activities occurring in pro-B/pre-B cells, they propose a theory to explain the apparent lineage specificity, stage specificity, and breakage at CpGs. The structure was adapted from PDB 3C2I and generated in UCSF Chimera. The histologic photo of the follicular lymphoma was a generous gift of Dr. Bharat Nathwani, USC.
Articles of Interest in Other Journals
- Developmental Cell
- The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development
- Ariadna Laguna, Sergi Aranda, María José Barallobre, Rima Barhoum, Eduardo Fernández, Vassiliki Fotaki, Jean Maurice Delabar, Susana de la Luna, Pedro de la Villa, Maria L. Arbonés
- Immunity
- Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells
- Jonathan A. Hill, Jason A. Hall, Cheng-Ming Sun, Qi Cai, Norbert Ghyselinck, Pierre Chambon, Yasmine Belkaid, Diane Mathis, Christophe Benoist
- Molecular Cell
- CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation
- Peter Mulligan, Thomas F. Westbrook, Matthias Ottinger, Natalya Pavlova, Bin Chang, Eric Macia, Yu-Jiang Shi, Jordi Barretina, Jinsong Liu, Peter M. Howley, Stephen J. Elledge, Yang Shi
Leading Edge
- In This Issue p975
- Cancer Biology Select p979
BenchMarks
Featured Article- On Viruses, Discovery, and Recognition p983
- Robin A. Weiss
- Green Fluorescent Protein Glows Gold p987
- Atsushi Miyawaki
Book Review
- The Shredding of a Caricature p991
- Alejandro Sánchez Alvarado
Correspondence
- No Association between CALHM1 and Alzheimer's Disease Risk p993
- Lars Bertram, Brit-Maren M. Schjeide, Basavaraj Hooli, Kristina Mullin, Mikko Hiltunen, Hilkka Soininen, Martin Ingelsson, Lars Lannfelt, Deborah Blacker, Rudolph E. Tanzi
- Response: CALHM1 Association with Alzheimer's Disease Risk p994
- Fabien Campagne, Jean-Charles Lambert, Ute Dreses-Werringloer, Valérie Vingtdeux, Corinne Lendon, Dominique Campion, Philippe Amouyel, Annette T. Lee, Peter K. Gregersen, Peter Davies, Philippe Marambaud
- Denominator Problems in a Muscle Stem Cell Study? p997
- Terence Partridge
- Response: Skeletal Muscle Precursor Grafts in Dystrophic Mice p998
- Massimiliano Cerletti, Kristen Stevenson, Donna Neuberg, Sara Jurga, Carol A. Witczak, Michael F. Hirshman, Jennifer L. Shadrach, Laurie J. Goodyear, Amy J. Wagers
Previews
- Counting Motors by Force p1000
- Daniel St Johnston
- Clash of the Genomes p1002
- Daniel A. Barbash
- Bcl-2 Proteins and Apoptosis: Choose Your Partner p1004
- Gordon C. Shore, Mai Nguyen
- Divided within: Heterogeneity within Adult Stem Cell Pools p1006
- Marc H.G.P. Raaijmakers, David T. Scadden
Minireviews
- Collateral Damage from Antigen Receptor Gene Diversification p1009
- Grace K. Mahowald, Jason M. Baron, Barry P. Sleckman
- HMGA2, MicroRNAs, and Stem Cell Aging p1013
- Scott M. Hammond, Norman E. Sharpless
Articles
- Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death p1017
- Xianqin Zhang, Shenghan Chen, Shin Yoo, Susmita Chakrabarti, Teng Zhang, Tie Ke, Carlos Oberti, Sandro L. Yong, Fang Fang, Lin Li, Roberto de la Fuente, Lejin Wang, Qiuyun Chen, Qing Kenneth Wang
- AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations p1028
- Davide F. Robbiani, Anne Bothmer, Elsa Callen, Bernardo Reina-San-Martin, Yair Dorsett, Simone Difilippantonio, Daniel J. Bolland, Hua Tang Chen, Anne E. Corcoran, André Nussenzweig, Michel C. Nussenzweig
- CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore p1039
- Tetsuya Hori, Miho Amano, Aussie Suzuki, Chelsea B. Backer, Julie P. Welburn, Yimin Dong, Bruce F. McEwen, Wei-Hao Shang, Emiko Suzuki, Katsuya Okawa, Iain M. Cheeseman, Tatsuo Fukagawa
- Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors p1053
- Sarah De Val, Neil C. Chi, Stryder M. Meadows, Simon Minovitsky, Joshua P. Anderson, Ian S. Harris, Melissa L. Ehlers, Pooja Agarwal, Axel Visel, Shan-Mei Xu, Len A. Pennacchio, Inna Dubchak, Paul A. Krieg, Didier Y.R. Stainier, Brian L. Black
- Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species p1065
- Hsin-Yi Lee, Jui-Yu Chou, Liplee Cheong, Nai-Hsin Chang, Shi-Yow Yang, Jun-Yi Leu
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax p1074
- Jonathan F. Lovell, Lieven P. Billen, Scott Bindner, Aisha Shamas-Din, Cecile Fradin, Brian Leber, David W. Andrews
- Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity p1085
- Debanjan Goswami, Kripa Gowrishankar, Sameera Bilgrami, Subhasri Ghosh, Riya Raghupathy, Rahul Chadda, Ram Vishwakarma, Madan Rao, Satyajit Mayor
- Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets p1098
- George T. Shubeita, Susan L. Tran, Jing Xu, Michael Vershinin, Silvia Cermelli, Sean L. Cotton, Michael A. Welte, Steven P. Gross
- Transepithelial Projections from Basal Cells Are Luminal Sensors in Pseudostratified Epithelia p1108
- Winnie Wai Chi Shum, Nicolas Da Silva, Mary McKee, Peter J.S. Smith, Dennis Brown, Sylvie Breton
- Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair p1118
- Anne Wilson, Elisa Laurenti, Gabriela Oser, Richard C. van der Wath, William Blanco-Bose, Maike Jaworski, Sandra Offner, Cyrille F. Dunant, Leonid Eshkind, Ernesto Bockamp, Pietro Lió, H. Robson MacDonald, Andreas Trumpp
Theory
- Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity p1130
- Albert G. Tsai, Haihui Lu, Sathees C. Raghavan, Markus Muschen, Chih-Lin Hsieh, Michael R. Lieber
SnapShot
- SnapShot: The Human DNA Methylome in Health and Disease p1144
- Esteban Ballestar, Manel EstellerPDF (1423 kb)
