15 June, 2010
Volume 18, Issue 6

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Volume 18, Issue 6

On the cover: Barrera et al. (pp. 913–926) show that the human microcephaly-associated gene Cdk5rap2 is required to maintain the bonds that keep centriole pairs together, thereby restricting centriole duplication. The cover art depicts the consequences of a Cdk5rap2 null mutation in mice: mitotic cells often have multipolar spindles in which the centrosomes contain single centrioles rather than the normal mother-daughter pair.


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Annotated Table
of Contents

Most Read Papers

  • These are the Most Read by download from the Developmental Cell website.


  • If you would like editorial input on whether your paper might be a strong candidate for consideration for Developmental Cell, you can send a presubmission inquiry using our online inquiry form.

Conference Attendance

This month, Developmental Cell's Editor, Deborah Sweet, will attend the annual meeting of the ISSCR in San Francisco as well as the International Vascular Biology Meeting hosted at UCLA. Dan Wainstock will be at the Santa Cruz Developmental Biology conference. We'll see you there!

Announcing the Inaugural Cell Symposium

Inflammation & Disease
» September 26–28, 2010 | Lisbon, Portugal
» Abstract submission deadline: June 1, 2010
» Register Now! | Submit your abstract.

Job Seekers: View the latest Jobs in Developmental Biology on the all-new Cell Career Network!

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In the June issue

Featured Article

Featured Article

In an effort to develop new ways of assaying gene expression in specific cell types, Deal et al. established a method for the isolation of nuclei exclusively from cells that express a specific transgene. This approach enables subsequent profiling not only of tissue-specific gene expression, but also of the chromatin composition and modifications that accompany it. Dr. Deal discusses this technique and demonstrates a key portion of it in the Video Abstract of the paper.

Access to the featured article is free, so check out how it looks in the Article of the Future format and tell us what you think!

Review Series

Tumors as organs: complex tissues that interface with the entire organism

Our series of reviews on organogenesis concludes this month with a piece by Egeblad, Nakasone, and Werb, discussing parallels between tumor development and organ formation, remodeling, and repair. To see the entire series, click here.

Issue Highlights

A genome-wide siRNA screen by Lipinski et al. reveals that in addition to nutrient levels, mammalian autophagy is regulated by an array of extracellular cues, including growth factors, cytokines, and chemokines, that signal through multiple mTOR-independent growth-regulatory pathways and converge on the type III PI3 kinase.

Multipotent pancreatic progenitors make an early fate decision between the acinar and ductal/endocrine lineages. Schaffer et al. now show that mutual repression between Nkx6 transcription factors and Ptf1a enables a bistable switch that allocates progenitors to these two respective cell lineages.
Also in this issue:
Aurora B is a chromosomal signal to spindle microtubules
Cdk5rap2 controls centriole engagement and duplication
Direct regulation of auxin transport links nitrate to root architecture
Wnt controls the vasculature via regulation of Dll4/Notch signaling
TRIM protein MADD-2 mediates netrin signaling (see Hao et al. and Alexander et al.)
Transcriptional control of ECM during gut looping
Flower isoforms mark winners and losers in cell competition
Ras switches blood-derived TNF from apoptotic to oncogenic
Ecdysone represses Myc in Drosophila fat to control systemic growth

Click here for the complete table of contents.

One Year Ago...

Elazar Zelzer and colleagues discovered that muscle contraction activates β-catenin in joint tissue, preventing local chondrogenesis.

The role of Polycomb proteins in chromatin organization and the loss of developmental plasticity was elucidated by Susan Mango's lab

Hao Yu's group showed that transcriptional regulators of flowering time also control floral patterning via direct repression of SEPALLATA3, a cofactor of the core homeotic protein LEAFY.

All archived Developmental Cell papers from a year or more ago are available free online.

Featured Topic

A selection of recent Developmental Cell and Trends journal articles highlighting the roles that scaffolding protein interactions play in directing cellular processes. For previous featured topics, click here.

The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells
Dan Du, Feilai Xu, Lihou Yu, Chenyi Zhang, Xuefeng Lu, Haixin Yuan, Qin Huang, Fan Zhang, Hongyan Bao, Lianghui Jia et al.

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded
Jianzhong Yu, Yonggang Zheng, Jixin Dong, Stephen Klusza, Wu-Min Deng, Duojia Pan

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Alice Genevet, Michael C. Wehr, Ruth Brain, Barry J. Thompson, Nicolas Tapon

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
Roland Baumgartner, Ingrid Poernbacher, Nathalie Buser, Ernst Hafen, Hugo Stocker

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
Anthony A. Lanahan, Karlien Hermans, Filip Claes, Joanna S. Kerley-Hamilton, Zhen W. Zhuang, Frank J. Giordano, Peter Carmeliet, Michael Simons

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration
Pascale G. Charest, Zhouxin Shen, Ashley Lakoduk, Atsuo T. Sasaki, Steven P. Briggs, Richard A. Firtel

ATRX Partners with Cohesin and MeCP2 and Contributes to Developmental Silencing of Imprinted Genes in the Brain
Kristin D. Kernohan, Yan Jiang, Deanna C. Tremblay, Anne C. Bonvissuto, James H. Eubanks, Mellissa R.W. Mann, Nathalie G. Béérubé

And from Trends journals:

Trends in Biochemical Sciences
The human Mediator complex: a versatile, genome-wide regulator of transcription
Dylan J. Taatjes

Multitasking with ubiquitin through multivalent interactions
Fen Liu, Kylie J. Walters

Trends in Cell Biology
Building RNA–protein granules: insight from the germline
Alexey L. Arkov, Andres Ramos

TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highways
Bruno Goud, Paul A. Gleeson

Filamins in cell signaling, transcription and organ development
Alex-Xianghua Zhou, John H. Hartwig, Levent M. Akyürek

Trends in Microbiology
Functional diversity of ankyrin repeats in microbial proteins
Souhaila Al-Khodor, Christopher T. Price, Awdhesh Kalia, Yousef Abu Kwaik

Trends in Neuroscience
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
Carsten Janke, Matthias Kneussel