12 December, 2008
Volume 135, Issue 6

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Volume 135, Issue 6

On the cover: Hematopoietic cancers, such as the follicular lymphoma pictured on the cover, frequently contain chromosomal translocations. However, the molecular mechanisms behind these DNA breakage and reshuffling events are largely unidentified. In this issue of Cell, Tsai et al. (pp. 1130–1142) show that CpG dinucleotides, like that colored in the molecular structure on the cover, are hotspots for pro-B/pre-B stage translocations—the most common translocations in human cancer. On the basis of the molecular activities occurring in pro-B/pre-B cells, they propose a theory to explain the apparent lineage specificity, stage specificity, and breakage at CpGs. The structure was adapted from PDB 3C2I and generated in UCSF Chimera. The histologic photo of the follicular lymphoma was a generous gift of Dr. Bharat Nathwani, USC.

Most Read Papers

  • These are the most read by download from the Cell web site for the last 30 days.

Basal cells make contact with lumen
Rather than sitting passively in the basement of epithelial tissues, basal cells (red) are now seen to send slender extensions towards tight junctions (green) at the lumen. In the case of the epididymis as shown here in a 3D confocal reconstruction, these extensions seem to play an active role in the regulation of the tissue's activities in response to signals in the lumen that lead to the activation of apical V-ATP pumps (blue) of neighboring cells. Nuclei and spermatozoa are also shown in blue. See also paper by Shum et al.



SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here, for a full list of SnapShots.


SnapShot: Cell-Cycle Regulators II
David O. Morgan

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In this Issue

Nuclear pore at the core of heart rhythm
AID at both sides of chromosomal translocations: Robbiani et al. and Tsai et al.
CENP-T/W at the center of centromeres
Endothelia enhancer revealed
Speciation genes discovered in yeast
Membrane permeabilization frame by frame
Beyond thermodynamics in membrane organization
More motors for cargo transport—same speed
Basal cells breach the lumen
HSC asleep, but on call

Immediate Early Publication

Real-Time Visualization of Dynamin-Catalyzed Membrane Fission and Vesicle Release
Thomas J. Pucadyil, and Sandra L. Schmid

GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission
Pavel V. Bashkirov, Sergey A. Akimov, Alexey I. Evseev, Sandra L. Schmid, Joshua Zimmerberg, and Vadim A. Frolov

Featured Article

Featured articles are freely available to all readers

Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species
Hybrid sterility is a phenomenon that often occurs when two species are crossed, but the resulting offspring is infertile. By screening hybrids of two yeast species, Lee et al. identify a pair of genes responsible for this hybrid incompatibility. The results reveal insights into the mechanism of mitochondrial and nuclear genome incompatibility as an important step in speciation.
In this PaperClip, Dr. Britta Mädge speaks with Dr. Jun-Yi Leu about his group’s identification of hybrid incompatibility genes in yeast.

Dr. Jun-Yi Leu

Leading Edge Featured Articles

In this issue’s Leading Edge, we feature two articles by Robin Weiss and Atsushi Miyawaki that pay tribute to this year’s Nobel Prize Winners in Physiology or Medicine and Chemistry, respectively.

On Viruses, Discovery, and Recognition
Robin A. Weiss

Green Fluorescent Protein Glows Gold
Atsushi Miyawaki

Cell PaperClips

Dr. Rong Li Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor
Dr. Karen Carniol speaks with Dr. Rong Li about her group’s study on the evolvability of cellular processes and the role of polyploidization and aneuploidization therein.

You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, click here

Cell Podcast

In our latest podcast, we hear from Dr. Nathaniel Heintz about "TRAP," a new technique reported in Cell for looking at gene expression in the brain. Then we learn about a study in Current Biology from Dr. Robert Fleischer regarding the curious classification of the Hawaiian honeyeater. And we will also hear from Dr. Alan Beggs about his study in the American Journal of Human Genetics presenting a large-scale screen for mutations involved in Diamond-Blackfan anemia.

And stay tuned for a round-up of some of the exciting research advances recently published in Cell and the Cell Press family of journals.

You can listen directly by clicking on the player above. To learn about other ways to listen to the podcast, click here.