14 November, 2008
Volume 29, Issue 5

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Volume 29, Issue 5

On the cover: Granzyme A is thought to be an important inducer of cell death. However, Metkar et al. (pp. 720–733) suggest that it has a more important role in the induction of proinflammatory cytokines. The cover shows a rendition of the two-faced Roman god Janus. The right face views the concept in which the granule secretory pathway is entirely devoted to cell death. The left face looks toward the new concept that cytotoxic cells also may play a part in mediating inflammatory reactions. The grape-like structures on the headband represent the phenomenon of cytotoxic cell-granule-mediated apoptosis and its balanced repositioning in the face of the new information. The illustration was conceived by Jacqueline Froelich (graphite on linen paper) with acrylics by Jamie Froelich. See also the Preview by Trapani and Bird (pp. 665–667).

One year ago ...

Selected articles from a year ago.

Mellman and colleagues found disruption of E-cadherin-mediated adhesion induces dendritic cells with tolerogenic properties.

Núñez and colleagues review the NOD-like family of intracellular microbial sensors.

All archived articles older than one year are available free online.

Online Ahead of Issue

Autoreactive B Cell Receptors Mimic Autonomous Pre-B Cell Receptor Signaling and Induce Proliferation of Early B Cells
Fabian Köhler, Eva Hug, Cathrin Eschbach, Sonja Meixlsperger, Elias Hobeika, Juliane Kofer, Hedda Wardemann, and Hassan Jumaa
Summary | Full Text | PDF | Supplemental Data 

Most Read Papers

These are the Most Read Papers by download from the Immunity website for the last 30 days.

Current Issue

Featured article (freely available):

Retinoic acid enhances Treg cell
conversion via a third party

Article by Benoist and colleagues

On the cover: Re-examining Granzyme A

Next issue: December 18, 2008

Also In This Issue


Uric acid signaling

Uric acid (UA) crystals have adjuvant properties, but a receptor for UA has not been identified. Shi and colleagues report that UA may interact directly with cholesterol within dendritic cell (DC) membranes to stimulate DCs in a protein-receptor-independent manner. Preview by DeFranco.


Human B cell tolerance

Both central and peripheral tolerance checkpoints help to eliminate autoreactive B cells. Meffre and colleagues find that the signaling molecules IRAK-4 and MyD88 are essential for both central and peripheral checkpoints whereas UNC93B is also important for the peripheral checkpoint. Preview by Bolland.


Notch another regulation

Because of the potency of Toll-like receptors (TLRs) to sense antigens and initiate immune responses, they need to be tightly regulated. Ivashkiv and colleagues show an intricate coordination among TLRs, Notch and interferon-γ signaling. Preview by Hertzog.


Clustering dynamics

The dynamics of a granulomatous response during bacterial infection is vague. Locksley and colleagues observe that dendritic cells activated by Listeria promote the clustering of NK cells and monocytes, which in turn interact for functional activation to contain the pathogen. Preview by Serbina and Pamer.


Special Issue: Mucosal Immunity
Trends in Immunology

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens
Zijiang Zhao, Blima Fux, Megan Goodwin, Ildiko R. Dunay, David Strong, Brian C. Miller, Ken Cadwell, Monica A. Delgado, Marisa Ponpuak, Karen G. Green, Robert E. Schmidt, Noboru Mizushima, Vojo Deretic, L. David Sibley, and Herbert W. Virgin
Cell Host and Microbe

DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating Inflammatory Gene Expression
Rupak Mukhopadhyay, Partho Sarothi Ray, Abul Arif, Anna K. Brady, Michael Kinter, and Paul L. Fox
Molecular Cell