5 December, 2008
Volume 32, Issue 5
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Volume 32, Issue 5
On the cover: The high-density genetic interaction map of factors involved in RNA processing described in this issue begins to untangle a complex network of functional relationships. As described by Wilmes et al. (p. 735) and also in the accompanying manuscript by Kress et al. (p. 727), this genetic interaction map aided in the elucidation of additional functions for previously described factors and also suggests roles for previously uncharacterized factors. Furthermore, as represented by the bird and serpent emerging from the tapestry depicted in the cover image, systems-level analysis of the data set gives rise to some insight into the global interactions among complexes and pathways that contribute to the dynamic cycle of creation and destruction of RNA molecules within the cell.
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- In This Issue
- Featured Article
- Featured Review
- Featured Topic
- Molecular Mechanisms
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Announcements
Molecular Cell congratulates Robert Tjian, member of its Editorial Board, for his election as the new President of the Howard Hughes Medical Institute.
Molecular Cell congratulates Victor Ambros, David Baulcombe, and Gary Ruvkun for the 2008 Albert Lasker Basic Medical Research Award recognizing their pioneering efforts in discovering small regulatory RNAs.
Molecular Cell congratulates Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien for the 2008 Nobel Prize in Chemistry honoring their work on Green Fluorescent Protein, GFP.
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UT Southwestern is pleased to announce the continuation of the Endowed Program for Scholars in Biomedical Research. The Program, which is fully funded from private endowment, will provide at least $1,000,000 over four years to support the research activities of each new Assistant Professor (tenure track) appointed to the Program; five will be appointed annually. For more information visit click here.
Molecular Mechanisms @ Cell Press
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Philipp Oberdoerffer, Shaday Michan, Michael McVay, Raul Mostoslavsky, James Vann, Sang-Kyu Park, Andrea Hartlerode, Judith Stegmuller, Angela Hafner, Patrick Loerch, Sarah M. Wright, Kevin D. Mills, Azad Bonni, Bruce A. Yankner, Ralph Scully, Tomas A. Prolla, Frederick W. Alt, and David A. Sinclair
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Karyn L. Sheaffer, Dustin L. Updike, and Susan E. Mango
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Hye-Sook Kwon and Melanie Ott
- Trends in Genetics
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Volume 32 Issue 5: December 4, 2008
*FREE REVIEW*
David M. Lonard, Bert W. O'Malley *FREE TiBS REVIEW*
Miriam Calao, Arsène Burny, Vincent Quivy, Ann Dekoninck, Carine Van Lint Maria Divina E. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, Robert Tjian Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Le Guezennec, Hendrik G. Stunnenberg, Aleksey Krasnov, et al. Xiao-Yong Zhang, Maya Varthi, Stephen M. Sykes, Charles Phillips, Claude Warzecha, Wenting Zhu, Anastasia Wyce, Alan W. Thorne, Shelley L. Berger, Steven B. McMahon Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan et al. Andrea V. Gómez, Danny Galleguillos, Juan Cristóbal Maass, Elena Battaglioli, Manuel Kukuljan, María Estela Andrés Jeong Hoon Kim, Catherine K. Yang, Kyu Heo, Robert G. Roeder, Woojin An, Michael R. Stallcup Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A. Ohgi, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld Ping Yi, Qin Feng, Larbi Amazit, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley
Current Issue
Volume 32 Issue 5: December 4, 2008
Next issue: December 24, 2008
Included in this issue:
COP1 and ELF3 regulate GI stability to control circadian function
Conserved states of the Hsp90 ATPase cycle
APC protects β-catenin from dephosphorylation by PP2A
siRNA-directed DNA methylation in nucleolar dominance
HP1a stimulates H3K36 demethylation by dKDM4A
Promoter recognition by phage N4 virion RNA polymerase
Conserved states of the Hsp90 ATPase cycle
APC protects β-catenin from dephosphorylation by PP2A
siRNA-directed DNA methylation in nucleolar dominance
HP1a stimulates H3K36 demethylation by dKDM4A
Promoter recognition by phage N4 virion RNA polymerase
Click here for the complete Table of Contents.
Featured Articles
The Featured Articles are freely available to all readers
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Tumorigenesis is caused by activation of oncogenes and inactivation of tumor suppressor genes. Mulligan et al. report that CDYL bridges the histone methyltransferase G9a and the tumor suppressor REST to repress transcription and cellular transformation. |
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SR proteins play key roles in pre-mRNA splicing in mammals. Kress et al. demonstrate that a yeast SR-like protein, Npl3, affects splicing of many pre-mRNAs by a mechanism involving co-transcriptional recruitment of splicing factors to chromatin. |
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All functional RNAs undergo a series of maturation events collectively termed RNA processing. Wilmes et al. report a high-density genetic interaction map of RNA processing factors that revealed many functional connections, including links between the splicing and export machineries and the proteasome component Sem1/Dss1. |
Featured Review
The Featured Review is freely available to all readers
 |
The Control of mRNA Decapping and P-Body Formation Tobias M. Franks and Jens Lykke-Andersen mRNA regulation is critical for proper gene expression, and cells utilize many pathways to achieve such control. In this Review, Toby Franks and Jens Lykke-Anderson describe a kinetic model for how translational repression, mRNP multimerization, and mRNA decay direct mRNP assembly into P bodies. |
Featured Topic
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Coregulators of transcription, coactivators and corepressors, are often found in multiprotein complexes that assist in the communication between transcription factors and RNA polymerase II. The following selection of articles and FREE Reviews samples some of the interesting mechanisms by which coregulators work to regulate the activities of sequence-specific transcription factors. |
David M. Lonard, Bert W. O'Malley *FREE TiBS REVIEW*
Miriam Calao, Arsène Burny, Vincent Quivy, Ann Dekoninck, Carine Van Lint Maria Divina E. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, Robert Tjian Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Le Guezennec, Hendrik G. Stunnenberg, Aleksey Krasnov, et al. Xiao-Yong Zhang, Maya Varthi, Stephen M. Sykes, Charles Phillips, Claude Warzecha, Wenting Zhu, Anastasia Wyce, Alan W. Thorne, Shelley L. Berger, Steven B. McMahon Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan et al. Andrea V. Gómez, Danny Galleguillos, Juan Cristóbal Maass, Elena Battaglioli, Manuel Kukuljan, María Estela Andrés Jeong Hoon Kim, Catherine K. Yang, Kyu Heo, Robert G. Roeder, Woojin An, Michael R. Stallcup Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A. Ohgi, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld Ping Yi, Qin Feng, Larbi Amazit, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley
