5 December, 2008
Volume 32, Issue 5

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Volume 32, Issue 5

On the cover: The high-density genetic interaction map of factors involved in RNA processing described in this issue begins to untangle a complex network of functional relationships. As described by Wilmes et al. (p. 735) and also in the accompanying manuscript by Kress et al. (p. 727), this genetic interaction map aided in the elucidation of additional functions for previously described factors and also suggests roles for previously uncharacterized factors. Furthermore, as represented by the bird and serpent emerging from the tapestry depicted in the cover image, systems-level analysis of the data set gives rise to some insight into the global interactions among complexes and pathways that contribute to the dynamic cycle of creation and destruction of RNA molecules within the cell.

Most Read Papers

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Presubmission Inquiries

  • If you would like editorial input on whether your paper might be a strong candidate for consideration, you can send a presubmission inquiry to Molecular Cell. This should include an abstract plus a brief description of the results and an explanation of the significance to the readership of Molecular Cell.



Molecular Cell congratulates Robert Tjian, member of its Editorial Board, for his election as the new President of the Howard Hughes Medical Institute.

Molecular Cell congratulates Victor Ambros, David Baulcombe, and Gary Ruvkun for the 2008 Albert Lasker Basic Medical Research Award recognizing their pioneering efforts in discovering small regulatory RNAs.

Molecular Cell congratulates Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien for the 2008 Nobel Prize in Chemistry honoring their work on Green Fluorescent Protein, GFP.

Featured Job

Endowment for Scholars
Biomedical Research
The University of Texas Southwestern Medical Center

UT Southwestern is pleased to announce the continuation of the Endowed Program for Scholars in Biomedical Research. The Program, which is fully funded from private endowment, will provide at least $1,000,000 over four years to support the research activities of each new Assistant Professor (tenure track) appointed to the Program; five will be appointed annually. For more information visit click here.

More Scientific Jobs

Molecular Mechanisms @ Cell Press

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
Philipp Oberdoerffer, Shaday Michan, Michael McVay, Raul Mostoslavsky, James Vann, Sang-Kyu Park, Andrea Hartlerode, Judith Stegmuller, Angela Hafner, Patrick Loerch, Sarah M. Wright, Kevin D. Mills, Azad Bonni, Bruce A. Yankner, Ralph Scully, Tomas A. Prolla, Frederick W. Alt, and David A. Sinclair

Current Biology
The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging
Karyn L. Sheaffer, Dustin L. Updike, and Susan E. Mango

Trends in Biochemical Sciences
The ups and downs of SIRT1
Hye-Sook Kwon and Melanie Ott

Trends in Genetics
Autophagy and aging: keeping that old broom working
Ana Maria Cuervo

Current Issue

Volume 32 Issue 5: December 4, 2008
Next issue: December 24, 2008

Included in this issue:

COP1 and ELF3 regulate GI stability to control circadian function
Conserved states of the Hsp90 ATPase cycle
APC protects β-catenin from dephosphorylation by PP2A
siRNA-directed DNA methylation in nucleolar dominance
HP1a stimulates H3K36 demethylation by dKDM4A
Promoter recognition by phage N4 virion RNA polymerase

Click here for the complete Table of Contents.

Featured Articles

The Featured Articles are freely available to all readers

CDYL bridges G9a and REST
Tumorigenesis is caused by activation of oncogenes and inactivation of tumor suppressor genes. Mulligan et al. report that CDYL bridges the histone methyltransferase G9a and the tumor suppressor REST to repress transcription and cellular transformation.
Npl3 promotes pre-mRNA splicing
SR proteins play key roles in pre-mRNA splicing in mammals. Kress et al. demonstrate that a yeast SR-like protein, Npl3, affects splicing of many pre-mRNAs by a mechanism involving co-transcriptional recruitment of splicing factors to chromatin.
Genetic interaction map of RNA processing factors
All functional RNAs undergo a series of maturation events collectively termed RNA processing. Wilmes et al. report a high-density genetic interaction map of RNA processing factors that revealed many functional connections, including links between the splicing and export machineries and the proteasome component Sem1/Dss1.

Featured Review

The Featured Review is freely available to all readers

The Control of mRNA Decapping and P-Body Formation
Tobias M. Franks and Jens Lykke-Andersen

mRNA regulation is critical for proper gene expression, and cells utilize many pathways to achieve such control. In this Review, Toby Franks and Jens Lykke-Anderson describe a kinetic model for how translational repression, mRNP multimerization, and mRNA decay direct mRNP assembly into P bodies.

Featured Topic

Coregulators of transcription, coactivators and corepressors, are often found in multiprotein complexes that assist in the communication between transcription factors and RNA polymerase II. The following selection of articles and FREE Reviews samples some of the interesting mechanisms by which coregulators work to regulate the activities of sequence-specific transcription factors.

Nuclear Receptor Coregulators: Judges, Juries, and Executioners of Cellular Regulation
David M. Lonard, Bert W. O'Malley

A pervasive role of histone acetyltransferases and deacetylases in an NF-κB-signaling code
Miriam Calao, Arsène Burny, Vincent Quivy, Ann Dekoninck, Carine Van Lint

MyoD Targets TAF3/TRF3 to Activate Myogenin Transcription
Maria Divina E. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, Robert Tjian

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing
Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Le Guezennec, Hendrik G. Stunnenberg, Aleksey Krasnov, et al.

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression
Xiao-Yong Zhang, Maya Varthi, Stephen M. Sykes, Charles Phillips, Claude Warzecha, Wenting Zhu, Anastasia Wyce, Alan W. Thorne, Shelley L. Berger, Steven B. McMahon

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation
Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan et al.

CoREST Represses the Heat Shock Response Mediated by HSF1
Andrea V. Gómez, Danny Galleguillos, Juan Cristóbal Maass, Elena Battaglioli, Manuel Kukuljan, María Estela Andrés

CCAR1, a Key Regulator of Mediator Complex Recruitment to Nuclear Receptor Transcription Complexes
Jeong Hoon Kim, Catherine K. Yang, Kyu Heo, Robert G. Roeder, Woojin An, Michael R. Stallcup

TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints
Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A. Ohgi, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld

Atypical Protein Kinase C Regulates Dual Pathways for Degradation of the Oncogenic Coactivator SRC-3/AIB1
Ping Yi, Qin Feng, Larbi Amazit, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley

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