December, 2008
Volume 26, Issue 12

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Volume 26, Issue 12

Lipids are a highly diverse class of molecules with crucial roles in cellular energy storage, structure and signalling. Lipid homeostasis is fundamental to the maintenance of health, and lipid defects are central to the pathogenesis of important and devastating diseases. Newly emerging advances have facilitated the development of so-called `lipidomics' technologies and offer an opportunity to elucidate the mechanisms leading to disease. On pages 647 to 652 in this issue, Matej Orešič and colleagues argue that tissues with limited allostatic capacity, such as the eye, could be used as readouts of metabolic stress over time and might provide a window to unknown pathogenic mechanisms, as well as facilitating identification of early biomarkers of disease. The cover image shows an example of diabetic retinopathy (left) in comparison with a retinal scan of a healthy eye (right). Images courtesy of Ray Small BSc MCOptom. Cover design by Philip Patenall.



Editorial Team

  • Editor
    Petra Gross
  • Portfolio Coordinator, Chemical Biology
    Milka Kostic
  • Production Editor
    Lewis Packwood
  • Editorial Assistant
    Katherine Wright
  • Illustrations and Design
    Lara Crow
    Mat McCutcheon
    Philip Patenall
    Neill Sharp

Featured Article

Structure-based antigen design: a strategy for next generation vaccines
Philip R. Dormitzer , Jeffrey B. Ulmer , and Rino Rappuoli
10.1016/j.tibtech.2008.08.002
Abstract | |


About Trends in Biotechnology

Trends in Biotechnology is unique in drawing together a wide readership of scientists and engineers from the many disciplines of the applied biosciences. As in the successful biotechnology companies and leading academic research groups, Trends in Biotechnology reflects the view that biotechnology is the integrated use of many biological technologies - from molecular genetics to biochemical engineering. This integration is essential for the effective translation of novel research into application. The journal addresses what is new, significant and practicable.

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Most Read Articles

These are the five most downloaded papers for the 30 days preceding. See full list of most read articles

Can yeast systems biology contribute to the understanding of human disease?
Dina Petranovic, Jens Nielsen
10.1016/j.tibtech.2008.07.008
Summary | |
The challenges of regulating stem cell-based products
Barbara J. von Tigerstrom
10.1016/j.tibtech.2008.08.004
Summary | |
Fluorescence complementation: an emerging tool for biological research
Y. John Shyu, Chang-Deng Hu
10.1016/j.tibtech.2008.07.006
Summary | |
Structure-based antigen design: a strategy for next generation vaccines
Philip R. Dormitzer, Jeffrey B. Ulmer, Rino Rappuoli
10.1016/j.tibtech.2008.08.002
Summary | |
Genetic design: rising above the sequence
Jonathan A. Goler, Brian W. Bramlett, Jean Peccoud
10.1016/j.tibtech.2008.06.003
Summary | |