December, 2008
Volume 26, Issue 12

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Volume 26, Issue 12

Lipids are a highly diverse class of molecules with crucial roles in cellular energy storage, structure and signalling. Lipid homeostasis is fundamental to the maintenance of health, and lipid defects are central to the pathogenesis of important and devastating diseases. Newly emerging advances have facilitated the development of so-called `lipidomics' technologies and offer an opportunity to elucidate the mechanisms leading to disease. On pages 647 to 652 in this issue, Matej Orešič and colleagues argue that tissues with limited allostatic capacity, such as the eye, could be used as readouts of metabolic stress over time and might provide a window to unknown pathogenic mechanisms, as well as facilitating identification of early biomarkers of disease. The cover image shows an example of diabetic retinopathy (left) in comparison with a retinal scan of a healthy eye (right). Images courtesy of Ray Small BSc MCOptom. Cover design by Philip Patenall.

Editorial Team

  • Editor
    Petra Gross
  • Portfolio Coordinator, Chemical Biology
    Milka Kostic
  • Production Editor
    Lewis Packwood
  • Editorial Assistant
    Katherine Wright
  • Illustrations and Design
    Lara Crow
    Mat McCutcheon
    Philip Patenall
    Neill Sharp

Featured Article

Structure-based antigen design: a strategy for next generation vaccines
Philip R. Dormitzer , Jeffrey B. Ulmer , and Rino Rappuoli
Abstract | |

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Structure-based antigen design: a strategy for next generation vaccines
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