March, 2011
Volume 27, Issue 3

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Volume 27, Issue 3

The relative roles that genes, environment, and their interactions play in shaping the genetic architecture of common complex diseases and disease risk can be viewed as the pieces of a fascinating, multi-dimensional puzzle. Deciphering gene-environment interactions and their mechanisms will be especially critical for solving this puzzle. On pages 107–115 of this issue, Ober and Vercelli describe, focusing on asthma as a model disease, recent advances and challenges in elucidating the molecular mechanisms underlying these interactions. This figure was conceived and designed by Minal Çalışkan, Amy Hart, and Jessica Chong.



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Editorial Team

  • Editor
    Joël Savard
  • Executive Editor, Molecular Biology
    Feng Chen
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    Basil Nyaku
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    Janet Adove-Nucaza

Advisory
Editorial Board

  • Katheryn V. Anderson
    Andy Clark
    Charles Epstein
    Gerald Fink
    Walter J. Gehring
    David Goldstein
    Leonard Guarente
    Yoshihide Hayashizaki
    Stephen Henikoff
    Jonathan Hodgkin
    H.Robert Horvitz
    Laurence Hurst
    Monica Justice
    Eugene Koonin
    Elliot Meyerowitz
    Sergio Moreno
    Claudio Scazzocchio
    James Smith
    Masatoshi Takeichi
    Diethard Tautz
    Olivier Voinnet
free article

Featured Article

Gene–environment interactions in human disease: nuisance or opportunity?
Carole Ober, and Donata Vercelli
10.1016/j.tig.2010.12.004
Abstract | |
Genome organization influences partner selection for chromosomal rearrangements
Patrick J. Wijchers, and Wouter de Laat
10.1016/j.tig.2010.11.001
Abstract | |

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Trends in Genetics

The most established monthly journal in Genetics, with articles from genetics to systems biology. Each issue contains concise, lively and up-to-date Reviews and Opinions. Reviews are invited from leading researchers in a specific field and objectively chronicle recent and important developments, while Opinions provide a forum for debate and hypothesis.

Most Read Articles RSS Icon Article Feed

These are the five most downloaded papers for the 30 days preceding March 27, 2011. See full list of most read articles

A twin approach to unraveling epigenetics
Jordana T. Bell, Tim D. Spector
10.1016/j.tig.2010.12.005
Summary | |
Gene–environment interactions in human disease: nuisance or opportunity?
Carole Ober, Donata Vercelli
10.1016/j.tig.2010.12.004
Summary | |
Understanding splicing regulation through RNA splicing maps
Joshua T. Witten, Jernej Ule
10.1016/j.tig.2010.12.001
Summary | |
Genome organization influences partner selection for chromosomal rearrangements
Patrick J. Wijchers, Wouter de Laat
10.1016/j.tig.2010.11.001
Summary | |
DNA double-strand break repair and the evolution of intron density
Ashley Farlow, Eshwar Meduri, Christian Schlötterer
10.1016/j.tig.2010.10.004
Summary | | | Supplemental Data