March, 2011
Volume 27, Issue 3

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Volume 27, Issue 3

The relative roles that genes, environment, and their interactions play in shaping the genetic architecture of common complex diseases and disease risk can be viewed as the pieces of a fascinating, multi-dimensional puzzle. Deciphering gene-environment interactions and their mechanisms will be especially critical for solving this puzzle. On pages 107–115 of this issue, Ober and Vercelli describe, focusing on asthma as a model disease, recent advances and challenges in elucidating the molecular mechanisms underlying these interactions. This figure was conceived and designed by Minal Çalışkan, Amy Hart, and Jessica Chong.



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Featured Article

Gene–environment interactions in human disease: nuisance or opportunity?
Carole Ober, and Donata Vercelli
10.1016/j.tig.2010.12.004
Abstract | |
Genome organization influences partner selection for chromosomal rearrangements
Patrick J. Wijchers, and Wouter de Laat
10.1016/j.tig.2010.11.001
Abstract | |

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Trends in Genetics

The most established monthly journal in Genetics, with articles from genetics to systems biology. Each issue contains concise, lively and up-to-date Reviews and Opinions. Reviews are invited from leading researchers in a specific field and objectively chronicle recent and important developments, while Opinions provide a forum for debate and hypothesis.

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These are the five most downloaded papers for the 30 days preceding March 27, 2011. See full list of most read articles

A twin approach to unraveling epigenetics
Jordana T. Bell, Tim D. Spector
10.1016/j.tig.2010.12.005
Summary | |
Gene–environment interactions in human disease: nuisance or opportunity?
Carole Ober, Donata Vercelli
10.1016/j.tig.2010.12.004
Summary | |
Understanding splicing regulation through RNA splicing maps
Joshua T. Witten, Jernej Ule
10.1016/j.tig.2010.12.001
Summary | |
Genome organization influences partner selection for chromosomal rearrangements
Patrick J. Wijchers, Wouter de Laat
10.1016/j.tig.2010.11.001
Summary | |
DNA double-strand break repair and the evolution of intron density
Ashley Farlow, Eshwar Meduri, Christian Schlötterer
10.1016/j.tig.2010.10.004
Summary | | | Supplemental Data