Agent-based modelling (ABM) and cellular automata (CA) are mathematical approaches in which autonomous entities (e.g. immunocytes) detect local information and act over time according to logical rules (e.g. established immunological principles). The power of this approach lies in the emergence of behaviour that arises from interactions between agents, which would otherwise be impossible to know a priori. On pages 589–599 Jason Papin and colleagues reveal the power of this approach for exploring myriad immunological processes. Cover design by Philip Patenall.
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