December, 2008
Volume 14, Issue 12

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Volume 14, Issue 12

On pp. 539–549 of this issue, Miguel López, Antonio Vidal-Puig and coauthors discuss the role of AMP-activated protein kinase (AMPK) in the control of energy homeostasis. Maintaining energy balance depends on the efficiency of tightly regulated mechanisms of energy intake and expenditure. Recent studies have shown that basic cellular metabolic pathways have a major role in the regulation of whole-body energy homeostasis. Among them, much interest and research has been focused on the AMPK pathway, a master sensor and regulator of energy homeostasis at the cellular level. Recently, this pathway has also been shown to be involved in the regulation of energy levels at the whole-body level; AMPK responds to hormones and nutrient signals in both peripheral tissues and the central nervous system to modulate metabolism, feeding behaviour and energy expenditure. Impairment of AMPK function is associated with metabolic alterations, insulin resistance, obesity, hormonal disorders and cardiovascular disease, and studies of the AMPK pathway and its tissue-specific regulation have the potential to provide new targets for the treatment of a range of metabolic disorders.



Editorial Team

  • Editor
    A. Romina Emilianus
  • Executive Editor, Molecular Medicine
    Charlotte Wang
  • Production Editor
    Lewis Packwood
  • Editorial Assistant
    Suado Nur
  • Illustrations and Design
    Lara Crow
    Mat McCutcheon
    Philip Patenall
    Neill Sharp

Featured Article

Epigenetic mechanisms in drug addiction
William Renthal , and Eric J. Nestler
10.1016/j.molmed.2008.06.004
Abstract | |


About Trends in Molecular Medicine

Trends in Molecular Medicine's is a leading biomedical review journal, providing reviews and comment on the latest breakthroughs in basic and translational research. This includes basic research aimed at understanding disease mechanisms, and translational research utilizing this information to develop new and improved molecular-targeted approaches for diagnosis, treatment and prevention. Molecular intervention also raises ethical, legal and financial issues. The journal’s objective is to provide a platform for discussion, analysis and debate of these topics across a diverse, multidisciplinary audience of basic scientists and clinicians, who share the common goal of understanding the molecular basis of disease with a view to new clinical practice. Communication of the emerging concepts and ideas will facilitate progress in this exciting and rapidly evolving new field of molecular medicine.

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Most Read Articles

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