December, 2008
Volume 29, Issue 12

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Volume 29, Issue 12

In this issue of the journal, J. Wess and colleagues discuss the conformational changes that are associated with the activation of GPCRs. They draw on recent disulfide cross-linking studies that have been carried out with the M3 muscarinic acetylcholine receptor in addition to the structural information that has been discerned from the crystal structures of β2-adrenergic receptors. The authors review the novel insights into receptor conformational change gained from these works.



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  • Editor
    Lekshmy Balakrishnan
  • Portfolio Coordinator, Chemical Biology
    Milka Kostic
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    Kirsty Strawbridge
  • Editorial Assistant
    Damien Robertson
  • Illustrations and Design
    Lara Crow
    Mat McCutcheon
    Philip Patenall
    Neill Sharp

Featured Article

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
Andrew B. Tobin , Adrian J. Butcher , and Kok Choi Kong
10.1016/j.tips.2008.05.006
Abstract | |


About Trends in Pharmacological Sciences

Trends in Pharmacological Sciences is one of the leading monthly review journals in pharmacology and toxicology. Every issue of Trends in Pharmacological Sciences contains succinct articles on the most exciting recent developments in pharmacology and toxicology research: topics covered in the journal range from molecular to behavioural pharmacology, and from current techniques to theoretical pharmacology. Trends in Pharmacological Sciences has a prestigious Advisory Editorial Board that attest to the journal's established reputation as essential reading for all pharmacologists and toxicologists, from students to professors and directors.

Review articles published in Trends in Pharmacological Sciences are lively, well-illustrated and have been thoroughly peer reviewed to ensure a balanced representation of the literature. Opinion articles follow trends and innovative ideas whilst the update section is designed to highlight recent advances in a particular research field providing insight on the implications of the new developments as well as future perspectives and directions. Letters of interest to readers are also published. Careful editing of all articles ensures accessibility to the non-specialist without compromising depth or quality for the specialist. Articles are usually invited; however, if you are interested in submitting a manuscript please send a one page summary of your proposed article to the editor.

Most Read Articles

These are the five most downloaded papers for the 30 days preceding. See full list of most read articles

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
Andrew B. Tobin, Adrian J. Butcher, Kok Choi Kong
10.1016/j.tips.2008.05.006
Summary | |
Stem-cell-derived products: an FDA update
Malcolm Moos
10.1016/j.tips.2008.09.003
Summary | |
Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
Francesc Villarroya, Pere Domingo, Marta Giralt
10.1016/j.tips.2004.12.005
Summary | |
Targeting the PIAS1 SUMO ligase pathway to control inflammation
Bin Liu, Ke Shuai
10.1016/j.tips.2008.07.008
Summary | |
G12/G13-mediated signalling in mammalian physiology and disease
Thomas Worzfeld, Nina Wettschureck, Stefan Offermanns
10.1016/j.tips.2008.08.002
Summary | |