This Viewpoint discusses the US Food and Drug Administration’s accelerated approval pathway and proposes the need for reforms as well as the timely completion of postapproval trials.
This Viewpoint discusses the rationale and data supporting the FDA’s accelerated approval of aducanumab for Alzheimer disease treatment.
This Viewpoint discusses the US Food and Drug Administration’s approval of aducanumab for the treatment of Alzheimer disease and considers the implications of the decision for the Medicare program.
This essay considers how routine drug screening for opioids can threaten the trust between patient and physician, transforming a partnership aimed at improving health into a dynamic of judge and accused.
This randomized clinical trial examines a decision support tool that provides lower back pain information and self-management recommendations that are specific to an individual’s characteristics, symptoms, and symptom progression.
This cohort study evaluates whether estimates of active and disabled life expectancy differ on the basis of neighborhood disadvantage after accounting for individual-level socioeconomic characteristics and other prognostic factors.
This cohort study examines the association of receipt of the Pfizer BNT162b2 mRNA or the Moderna mRNA-1273 vaccines in patients with cirrhosis compared with a propensity-matched control group of patients at similar risk of infection and severe disease from COVID-19.
This longitudinal ecological study estimates the associations between prison crowding, community COVID-19 transmission, and prison incidence rates of COVID-19.
This economic analysis examines more than 2.5 million insurance claims for anesthesia services paid to in- and out-of-network practitioners before and after surprise-billing legislation was passed in California, Florida, and New York.
This cohort study examines the association between prenatal antipsychotics exposure and the risk of birth and neurodevelopmental problems.
This cohort study evaluates the association between the timing of exposure to and severity of COVID-19 disease in close contacts of index patients with COVID-19.
This cohort study and meta-analysis examines differences by sex in US thyroid cancer incidence ratios compared with subclinical thyroid cancer rates at autopsy to understand more about gender inequities in thyroid cancer diagnosis.
This cohort study examines outcomes associated with chronic kidney disease as defined by a fixed vs an age-adapted estimated glomerular filtration rate threshold.
This randomized clinical trial assesses whether a blended collaborative care program for treating both heart failure and depression can improve clinical outcomes more than collaborative care for heart failure only and physicians’ usual care.
This Teachable Moment examines electronic prescription programs used within electronic health records and pharmacy systems.
This cross-sectional study assesses compliance within a random sample of hospitals with a federal rule requiring hospitals to disclose the prices they negotiate with insurers.
This cross-sectional study evaluated American Board of Medical Specialties member boards’ lactation-specific board examination accommodation policies and corroborated the outcomes of these policies by comparing the self-reported experiences of lactating or potentially lactating female physicians with board examinations.
This pre-post study examines the association between respiratory virus incidence and ambulatory antibiotic orders and the COVID-19 pandemic.
This cross-sectional study assesses national data for commercially insured and Medicare Advantage enrollees to analyze the use of levothyroxine in the US over time.
This study explores the shifts in total US sales and net prices for all 3 insulin glargine products from quarter 1 of 2010 through quarter 2 of 2020.
This cohort study examines the rate of SARS-CoV-2 reinfection among people in Lombardy, Italy, who previously recovered from COVID-19.
This cross-sectional study explores the frequency of, and rationale for, US Food and Drug Administration approval of high-risk therapeutic medical devices not meeting pivotal study primary end points from 2016 through 2020.
This cohort study compares rates at which patients with type 2 diabetes received diabetes-related health services prior to and during the COVID-19 pandemic.
This cross-sectional study uses 2017 and 2018 Medicare Part D clams to compare the amount Medicare pays for common generic prescriptions in Part D with prices available to patients without insurance at Costco.
This case report describes the electrocardiographic findings of a man in his 40s with palpitations lasting more than 30 hours, no prior symptoms, and a wide complex tachycardia with a rate of 180 beats/min.
This case report describes the electrocardiographic findings of a man in his 60s with a history of hypertension who presented to the emergency department with acute chest pain.
This case report presents the electrocardiographic findings of a patient in their 50s with intermittent rest angina, followed by continuous chest pain at rest.
This case report presents the electrocardiographic findings of a woman in her 50s with a history of long QT syndrome who presented to the emergency department with chest pain and presyncopal episodes.
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